Hawaii Biotech Receives Contract To Develop Dengue Vaccine

Hawaii Biotech, Inc. (HBI), announced today that the US Army SBIR Program awarded the company a Small Business Innovation Research (SBIR) Phase I contract to develop an effective dengue vaccine to protect military personnel against this potentially mission-aborting disease.

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Current leading dengue vaccine candidates in clinical trails offer only partial protection and long immunization periods. International travelers and military personnel being deployed to tropical or subtropical regions require more immediate and more complete immunity.

Specifically, HBI will develop and test novel adjuvants to enhance the immunogenicity of an inactivated dengue vaccine candidate. This effort takes the initial steps toward developing the world’s first vaccine capable of rapidly generating complete, lasting protection from dengue fever.

“The growing outbreak of dengue fever in Hawaii highlights the need for stronger containment efforts now, and a commitment to preventing additional outbreaks in the future. This vaccine has the potential to seriously improve the response to dengue fever both in Hawaii, and around the world, and I am pleased that the Army has awarded this important research and development contract to a local Hawaii business,” said Tulsi Gabbard.

“This contract will enable Hawaii Biotech to apply our many years of experience in viral vaccine development and our knowledge of the challenges in developing a dengue vaccine to this important mission,” said Elliot Parks, CEO.

In Phase I, HBI will select suitable adjuvant formulations and then demonstrate protective efficacy in a mouse model with a single dengue serotype. Upon successful completion of Phase I, HBI will be eligible to apply for Phase II funding that will continue development of the inactivated dengue vaccine candidate. This will include expanding the work to all four dengue serotypes to establish feasibility of the required tetravalent vaccine for dengue and additional preclinical efficacy studies. A successful Phase II outcome will provide the basis for advancement of the dengue vaccine into clinical trials needed for regulatory approval and commercialization.

This contract was funded by the Army SBIR Program. The work is managed by the US Army Medical Research and Materiel Command under Contract No. W81XWH-15-C-0120 and will be managed and done in collaboration with the Viral and Rickettsial Diseases Department at the Naval Medical Research Center.

The views, opinions and/or findings contained in this report are those of the author and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation. In conducting research using animals, the investigator will adhere to the Animal Welfare Act Regulations and other Federal statutes relating to animals and experiments involving animals and the principles set forth in the current version of the Guide for Care and Use of Laboratory Animals, National Research Council.

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